Analyzing the factors that influence occult metastasis in oral tongue cancer
신정현, 윤혜정, 김성민, 이종호, 명훈,
소속 상세정보
신정현 ( Shin Jung-Hyun ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
윤혜정 ( Yoon Hye-Jung ) - Seoul National University School of Dentistry Department of Oral Pathology
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이종호 ( Lee Jong-Ho ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
명훈 ( Myoung Hoon ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Objectives: We accessed the various clinico-histopathological factors, and their association with occult metastasis (OM) in oral tongue squamous cell carcinoma (OTSCC).
Materials and Methods: One hundred-nine patients with OTSCC were divided into the elective neck dissection (END) group and the watchful waiting (WW) group. Age, sex, T-stage, depth of invasion and differentiation were evaluated to determine the correlation between clinico-histopathological factors and OM. For immunohistochemical analysis, paraffin-embedded blocks of 41 OTSCC specimens were examined with antibodies (VEGF-c, c-Met, and ROR1).
Results: The group with tumor thickness of oral tongue cancer ≥3 mm had higher incidence of OM than those with a thickness of <3 mm. The depth of invasion was statistically correlated with OM (P=0.022). Immunohistochemical analysis showed that high expression of VEGF-c (P=0.043), c-Met (P=0.009), and ROR-1 (P=0.003) were statistically correlated with OM.
Conclusion: The analysis of these clinico-histopathological and immunohistochemical factors can help to determine neck dissection in clinically negative (cN0) patients.
키워드
Tongue cancer; Elective neck dissection; Watchful waiting; Occult metastasis; Immunohistochemistry
원문 및 링크아웃 정보
등재저널 정보